The sons of Jacob/Israel were Reuben, Simeon, Levi, Judah, Dan, Naphtali, Gad, Asher, Issachar, Zebulun, Jospeh and Benjamin. In Rev. 7:5-8 the same tribes are noted except that Dan is replaced by Manasseh, one of Joseph's sons. Significant? I don't suppose so. Interesting? Maybe.